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I have the opportunity to work with experienced and talented people, across many industries in a working environment that emphasizes collaboration. Cardno ENTRIX has given me the opportunity to leverage what I had learned in school and experience and apply it to real world issues. Cardno ENTRIX allows me to work on a wide range of projects and enjoy a diversified experience.

- Lauren Shapiro Federsel

Senior Project Consultant/Senior Geospatial Manager

Endocrine Disruptor Screening & Assessments

In response to scientific studies and public concern, Congress passed the Food Quality Protection Act and the Safe Drinking Water Act (SDWA) Amendments in 1996 requiring the EPA to screen certain pesticide chemicals for their potential effects on the human hormonal system.  Multiple chemical substances are suspected of interacting with endocrine systems, negatively affecting the health of people and wildlife.

The EPA continues to expand its Endocrine Disruptor Screening Program (EDSP) to protect the public.  In 2009, the agency identified a list of specific chemicals suspected of endocrine disrupting potential and began issuing testing orders to the producers of such chemicals.  Most recently, on November 17, 2010, the EPA issued a second list of chemicals requiring Tier 1 Screening, along with draft policies and procedures for screening SDWA chemicals and revised policies for test information collection activities.  EPA’s latest list, includes 134 identified water contaminants (both pesticides and other chemical substances) for screening and testing, broadening the 2009 list, which was exclusive to pesticide chemicals.  The agency’s 2010 list of chemicals and proposed policies deal with issues unique to the Safe Drinking Water Act and will supplement test orders issued previously for pesticides. 

Once new policies and procedures are finalized, the onus will be on chemical manufacturers, importers, processors and users to conduct the Tier 1 testing.  Complicating the situation, many companies affected by EPA’s latest recommendations, may be unfamiliar with previous testing policies if they are not in the pesticide market, making preparations for compliance even more difficult and time-consuming for some companies. 

While final changes remain to be seen because there is a 60-day period to respond to the EPA’s test plan, changes and additional testing requirements are a guarantee.  Advanced planning and preparation is critical.

Cardno ENTRIX is uniquely qualified to help

Cardno ENTRIX has significant experience in the technical matters associated with endocrine screening and testing as well as staff with years of industry experience in managing chemical regulatory issues.  We can provide a multidisciplinary team to help clients cost effectively respond to and comply with regulatory obligations for Endocrine Screening.

To discuss the strategy, development and implementation of an endocrine screening program at your firm, please contact,
Paul Mehrle, who leads Cardno ENTRIX’s national toxicology practice and is the Strategic Development Director of Product Safety & Compliance.  Paul can be reached by calling (573) 815-0006 or by clicking here.


  • Analyze the impact and business implications of the endocrine program and requirements on a company’s business
  • Assist clients in collecting and interpreting existing data on chemicals that could help firms in identifying testing needs and obtaining test waivers for specific tests
  • Oversee the laboratory testing required and interpret the data
    • Conduct the cell-based H295R Steroidogenesis Assay (Click here to read more)
  • Help develop and manage consortia that will be developed to meet the testing requirements

For More Information, email our Cardno ENTRIX experts by clicking here.